Eligibility for genetic testing
A Youngtimers Guide ・ Last Reviewed July 2, 2025Genetic testing can tell a person whether they carry a mutation that causes familial Alzheimer’s disease.
Familial Alzheimer's disease (FAD) is a rare, genetic form of Alzheimer’s disease caused by inheriting specific mutations in one of three genes: PSEN1, PSEN2, or APP. A genetic mutation in one of these genes can result in the gene not working normally, often causing FAD.
When a parent has one of these mutations, there's a 50% chance they could pass it on to each of their children.
Learn more about FAD genetics.
Am I eligible for genetic testing?
Genetic testing may be appropriate for people that meet the following criteria:
Family history: People from families in which Alzheimer’s disease was diagnosed or suspected in multiple family members across three or more generations, especially those that had symptoms before the age of 60.
Known genetic mutations: People from families with a known genetic mutation linked to familial Alzheimer's disease (i.e., someone in your family has tested positive for a mutation in PSEN1, PSEN2, or APP).
When it comes to FAD, genetic testing is appropriate for adults. Most professional organizations recommend against testing minors for adult-onset conditions unless there is a direct health benefit to the child during their childhood. Children may not fully understand the implications of genetic testing. When a person is an adult, they can make a more informed decision about whether to learn their genetic status.
What does it mean to “have the gene”?
You may hear people say they “have the gene” or say they want to find out if they “have the gene” for FAD. What people are referring to when they say that having a genetic mutation in one of the three genes associated with FAD (PSEN1, PSEN2, or APP).
Finding a genetic counselor
Before undergoing genetic testing, it’s important to speak with a qualified genetic counselor. This guide does not replace professional genetic counseling.